Comprehensive analysis of compositional interface fluctuations in planar lipid bilayer membranes.

Compositional interface dynamics within symmetric and asymmetric planar lipid bilayer membranes

Characterization of biophysical properties of single chloride channel in rat brain mitochondrial inner membrane by channel incorporation into bilayer lipid membrane

Introduction: Recent studies have shown the presence of Cl- channels in heart and liver mitochondrial membranes. In this work, we have characterized the functional profile of a Cl- channel from rat brain mitochondria. Methods: After removing and homogenizing the rat brain, the supernatant was separately centrifuged in MSEdigitonin, H2O and Na2CO3 and mitochondrial inner membrane vesicles wer...

Evidences for a new cation channel in the brain mitochondrial inner membrane

Introduction: Previous studies and our works have indicated several cation channels in the rat brain mitochondrial inner membrane. In this work, we report the single-channel characterization of a cation channel from the rat brain mitochondrial inner membrane incorporated into a planar lipid bilayer. Methods: After removing and homogenizing the adult rat brain, its supernatant was centrifuged...

Polyethylene Glycol Repairs Damaged Membrane; Biophysical Application of Artificial Planar Bilayer to Mimic Biological Membrane

Polyethylene glycol (PEG) is a hydrophilic polymer, known to be capable to fuse numerous single cells in vitro, to join the membranes of adjacent neurons and giant invertebrate axons, and to seal damaged neural membranes. The molecular mechanism of the action of PEG is still unknown. It is believed that PEG dehydrates membranes and enables their structural components to resolve and rearrange in...

What is the surface tension of a lipid bilayer membrane?

In a recent paper in this journal, Chiu et al. (1995) presented a molecular dynamics study of a planar lipid bilayer membrane in water with the explicit incorporation of a surface tension. Parallel to the membrane plane, a negative pressure of-100 atmospheres was applied, derived from the measured surface tension of a monolayer at an air/water interface. The same approach was put forward by Fel...